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2 edition of Bioassay of 4,4"-methylenebis-(n,n-dimethyl)benzenamine for possible carcinogenicity found in the catalog.

Bioassay of 4,4"-methylenebis-(n,n-dimethyl)benzenamine for possible carcinogenicity

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of 4,4"-methylenebis-(n,n-dimethyl)benzenamine for possible carcinogenicity

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  • 19 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Benzidine dyes -- Toxicology.,
  • Dyes and dyeing -- Toxicology.

  • Edition Notes

    StatementCarcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
    SeriesCarcinogenesis technical report series ; no. 186, DHEW publication ; no. (NIH) 79-1742, National Cancer Institute carcinogenesis technical report series -- no. 186., DHEW publication -- no. (NIH) 79-1742.
    ContributionsNational Institutes of Health (U.S.)
    The Physical Object
    Paginationxxi, 58 p. :
    Number of Pages58
    ID Numbers
    Open LibraryOL17538973M

    No part of this book may be reproduced or utilized i n any form or by any means, Currently,whenperfornunga bioassay, more emphasis is being placed on the analysis and possible reactions of the test chemical, '.Methylenebis(benzenamine). 4,4'-Methylenebis (2-chloroaniline) Ethion Aldicarb Nickel tetracarbonyl Isobenzan Pentaborane 1-Propenchlorodiol-diacetate Propyleneimine Oxygen difluoride Sulphur dichloride Selenium hexafluoride Hydrogen selenide TEPP Sulfotep Dimefox 1-Tri(cyclohexy)stannyl-1H-1,2,4-triazole Triethylenemelamine.


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Bioassay of 4,4"-methylenebis-(n,n-dimethyl)benzenamine for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Get this from a library. Bioassay of 4,4'-methylenebis(N, N-dimethyl)benzenamine for possible carcinogenicity. [Litton-Bionetics, inc.; National Institutes of. Under the conditions of this bioassay, 4,4'-methylenebis(N,N­ dimethyDbenzenamine was carcinogenic in Fischer 34 rats4, inducing thyroid follicular-cell carcinomas in both males and females.

Ad­ ministration of the compound was carcinogenic in female B6C3F1 mice, inducing liver neoplasms. There was no conclusive evidence that. 4,4′-methylenebis(N,N-dimethyl)benzenamine.

Properties 4,4′-Methylenebis(N,N-dimethyl)benzenamine is a bicyclic aro-matic amine that exists at room temperature as yellowish glisten-ing leaflets or plates or as tan crystals with a faint odor (NCIAkronHSDB ). Commonly referred to as Michler’s base,File Size: KB.

Search results for 4,4'-methylenebis at Sigma-Aldrich. Compare Products: Select up to 4 products. *Please select more than one item to compare. IUPAC Standard InChIKey: YBRVSVVVWCFQMG-UHFFFAOYSA-N CAS Registry Number: Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript.

Other names: Aniline, 4,4'-methylenedi-; p,p'-Diaminodiphenylmethane; p,p'-Methylenedianiline; Bis(p-aminophenyl)methane; Bis(4. Sufficient. NCI (a) conducted a bioassay of 4,4'-methylenebis(N,N- dimethylaniline) in rats and mice.

Groups of 50 male and 50 female F rats were given and ppm of the. 4,4'-Methylenebis(2-chloroaniline) (also known as MOCA, MBOCA, and bisamine) is a substance used as a curing agent in polyurethane production. MOCA is an aromatic amine which is structurally similar to benzidine, a known human bladder has been shown to cause hepatomas in mice and rats, lung and mammary carcinomas in rats and bladder cancer in : faint, amine-like.

Temperature (K) A B C Reference Comment; - Zalikin and Strepikheev, Coefficents calculated by NIST from author's data. Unfortunately, this book can't be printed from the OpenBook. Visit to get more information about this book, to buy it in print, or to download it as a free PDF.

The DuPont Chambers Works in Deepwater, N.J., was a major producer of two carcinogens (beta-naphthylamine and benzidine) and two suspected bladder carcinogens (ortho-toluidine and 4,4'-methylenebis [2-chloroaniline]). Hazard classification and labelling. The ‘Hazard classification and labelling’ section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP (Classification Labelling and Packaging) Regulation.

The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in.

The chemical properties of 4,4'- Methylenebis (2-Chloroaniline) indicate that about 43% will enter the water, 28% aquatic sediments, and 30% terrestrial soil. The concentration of 4,4'-Methylenebis (2-Chloroaniline) found in fish tissues is expected to be somewhat higher than the average concentration of 4,4'-Methylenebis (2-Chloroaniline) in.

2-Chlorobenzenamine. Molecular Weight: O-chloroaniline is a clear amber liquid with an amine odor. Occurs in both alpha and beta forms. (NTP, ) from CAMEO Chemicals. Expand this section. 2 Names and Identifiers. Expand this section. 3 Chemical and Physical Properties. Expand this section. 4 Spectral Information.

Expand this section. 4,4'-Methylenebis(phenyl isocyanate) acts as a monomer in the production of polyurethane. The rigid polyurethane foams are good thermal insulators, which find applications in all freezers and refrigerators, as well as in buildings.

It is also used as an industrial strength adhesive, which is available to end consumers as various high-strength. 4,4'-METHYLENEBIS(2-CHLOROANILINE) is a weak base. Undergoes an exothermic and self-sustaining decomposition reaction when exposed to heat above °F, In a closed container, the pressure buildup can be rapid enough to cause an explosion.

4,4′-METHYLENEBIS(2-CHLOROBENZENAMINE) 4,4′-Methylenebis(2-chlorobenzenamine) (MOCA) was considered by previous IARC Working Groups in, and (IARC, ). Since that time new data have become available, which have been incorporated in this Monograph, and taken into consideration in the present Size: KB.

Author(s): Litton-Bionetics, inc.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of 4,4'-methylenebis(N,N-dimethyl. This chemical inventory is OSHA's premier one-stop shop for occupational chemical information.

It compiles information from several government agencies and organizations. Information available on the pages includes: Chemical identification and physical properties Exposure limits Sampling information. (1) When required tests under Section (k)(2) reveal abnormalities, the tests should be repeated as soon as practicable within 30 days.

If the tests remain abnormal, consideration should be given to withdrawing the employee from contact with 4,4'-methylenebis(2-chloroaniline) while a more comprehensive examination is made. 4,4'-Methylenebis(N,N-dimethylaniline) ALS Environmental may or may not test for 4,4'-Methylenebis(N,N-dimethylaniline) (CAS # ).

Information is subject to change; please contact us for the latest available analytes for which we test. 4,4'-Methylenebis(phenyl isocyanate) testing. Laboratory testing for Methylene Diphenyl Diisocyanate is white to light yellow flakes or crystals.

Pamoic acid is a dicarboxylic acid. It derives from a 2-naphthoic acid. It is a conjugate acid of a pamoate (2-). Expand this section. 2 Names and Identifiers. Expand this section. 3 Chemical and Physical Properties.

Expand this section. 4 Spectral Information. Expand this section. 5 Related Records. Expand this section. 6 Chemical Vendors. 4,4'-Methylenebis(N,N-dimethylaniline) - California: carcinogen, initial date 10/1/89 NTP: Suspect carcinogen IARC: Group 2B carcinogen Other: See actual entry in RTECS for complete information.

Section 12 - Ecological Information Section 13 - Disposal Considerations Dispose of in a manner consistent with federal, state, and local regulations.

Objective: The objective of the study was to validate a new and simple method to determine MOCA in the urine of exposed workers. Methods: The separation, identification and quantification of urinary MOCA were performed in spiked urines by a sensitive and practical high-performance liquid chromatography (HPLC) method and applied to urine samples of 11 workers Cited by: 9.

4,4'-Methylenebis[2, 6-bis(hydroxymethyl) phenol] SMILES. c1c(cc(c(c1CO)O)CO)C c2cc(c(c(c2)CO)O)CO Copy. Std. InChi. InChI=1S/C17H20O6/c1 (( 9)16(12)22) ()17(23)15() /h,H,1,H2 Copy. Std. InChIKey. MWPXMEJTTYFHGR-UHFFFAOYSA-N Copy. Cite this record. High-throughput screening (HTS) assays that measure the in vitro toxicity of environmental compounds have been widely applied as an alternative to in vivo animal tests of chemical toxicity.

Current HTS studies provide the community with rich toxicology information that has the potential to be integrated into toxicity research. The available in vitro toxicity data is updated daily in structured Cited by: Predicted data is generated using the US Environmental Protection Agency’s EPISuite™.

Log Octanol-Water Partition Coef (SRC): Log Kow (KOWWIN v estimate) = Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v): Boiling Pt (deg C): (Adapted Stein & Brown method) Melting Pt (deg C): (Mean or Weighted MP) VP(mm Hg,25 deg C): E (Modified Grain. This volume of the IARC Monographs provides a reassessment of the carcinogenicity of about a dozen aromatic amines and organic dyes.

Additionally, occupational exposures of hairdressers and barbers and exposure from personal use of hair colourants were reviewed. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to.

Toxic Torts [is] a paradigm of taking an intelligent and methodological approach to the science/law interface.' Liz Fisher - University of Oxford Review of previous edition:‘Cranor's insightful discussions of science and law as it is seen by the Courts in toxic tort litigation is a ‘must read' for scientists in toxicology, epidemiology, and Cited by: 4, 4’-methylenebis-cyclohexanamine was introduced by Zhong et al.

[72] as a potential shale inhibitor. The inhibitive properties of the amine compound in comparison with currently available. 4,4-Methylenebis (2-chlorobenzenamine) No adequate epidemiological studies — — — 2-naphthylamine 12 75 25 0 Ortho-toluidine 5 80 20 0 PCB No human studies — — — 2,3,4,7,8-pentachlorodibenzofuran No human studies — — — Silica dust 10 90 Cited by: 5.

Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Subchronic Thyroid Toxicity Evaluation of 4,4′-Methylenebis(N, N ′-Dimethyl)Aniline in Fischer Rats June Journal of Toxicology and Environmental Health Part A 75(11) The Test Methods for Evaluating Solid Waste: Physical/Chemical Methods Compendium, also known as SW or the Compendium, is EPA’s official collection of methods for use in complying with the Resource Conservation and Recovery Act (RCRA) regulations.

SW is organized into chapters providing guidance on how to use the methods and groups of. 4,4'-Methylenebis (2-chloroaniline) (MBOCA) is a confirmed animal carcinogen. It is used commercially as a curing agent for polymers containing isocyanate. There are no adequate studies documenting a carcinogenic risk for MBOCA in humans; however, studies in.

o-Toluidine (ortho-toluidine) is an organic compound with the chemical formula CH 3 C 6 H 4 NH 2. It is the most important of the three isomeric toluidines. It is a colorless liquid although commercial samples are often yellowish.

It is a precursor to the herbicides metolachlor and ance: Colorless liquid. USA USA USA US A US A US A US A US A US A US A US A US A Authority US United States Prior art keywords isocyanate methylenebis phenyl isocyanate weight compositions Prior art date Legal status (The legal status is an assumption and is not a legal by: G.

Ramis-Ramos, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 4-Hexylresorcinol. 4-Hexylresorcinol is a pale yellow, viscous liquid (becoming solid on standing at room temperature) with a pungent faint fatty odor and a sharp astringent is an irritant, and its concentrated solutions can cause burns on the skin and mucous membranes.

@article{osti_, title = {EPA (Environmental Protection Agency) programs and the regulation of carcinogens: Methods and philosophies. Technical report}, author = {Jackson, M.

and Johnson, L. and Kelly, J. and Ledeboer, T. and Malave, M.}, abstractNote = {This paper discusses the manner in which the EPA identifies, assesses risk for, and regulates substances determined to cause cancer in.

The structural unit of the thyroid gland is the follicle, which is filled with the secretory product called colloid. Follicles are irregularly spheroid but vary greatly in shape and size with the largest follicles usually found near the periphery of the lobes (Figure ).The follicles are separated by a delicate fibrovascular stroma containing abundant capillaries, lymphatics, and nerves.

EPA/ September Application of Short-term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures Edited by Michael D. Waters Stephen Nesnow Joellen L Huisingh Shahbeg S.

Sandhu Larry Claxton Biochemistry Branch Environmental Toxicology Division Health Effects Research Laboratory U.S. Environmental Protection Agency Research Triangle Park. Weisburger EK, Murthy AS, Lilja HS, Lamb JC. Neoplastic response of F rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'4'-oxydianiline, and 4,4'4'-methylenedianiline.

J Natl Cancer Inst. 72(6): – Links. Google ScholarAuthor: Thomas A. Lewandowski.oswer directive *60 interim final rcra facility investigation (rfi) guidance volume i of iv development of an rfi work plan and erations for rcra facility investigations epa /sw may waste management division office of solid waste u.s.

environmental protection agency.